MOBTAKERAN
SALAMAT
FAKHER
Non-Invasive Flow Ratio (NiFFR) developed by Cardiac Computational Simulation Service (CCSS) in Mobtakeran Salamat Fakher (MSF), is coronary physiology simulation software used for the qualitative and quantitative analysis of blood flow. This software provides a non-invasive method of estimating fractional flow reserve (FFR), Wall Shear Stress (WSS) and Index of Microvascular Resistance (IMR) using standard analysis from angiography images. We herein introduce a computational angiography Software (C Angio) drawing upon mathematical equations to measure FFR based on coronary angiography images with less run time without need for adenosine and pressure wire. This Software aimed at augmenting the utility of FFR assessment for patients with intermediate and borderline coronary stenosis. The computational simulation of FFR and hemodynamic parameters such as WSS is a safe, efficient, and cost-effective method to evaluate the severity of coronary stenosis.
Computational Angiography Software
NiFFR
Non-Invasive Fractional Flow Reserved
MOBTAKERAN
SALAMAT
FAKHER
The claimed benefits of (C Angio):
A. Analysis is done using standard X-Ray Angiography images, without the need for additional imaging, radiation or medication.
B. It allows physicians to evaluate anatomic and physiologic coronary artery disease and accurately determine which coronary lesions are responsible for myocardial ischemia, avoiding unnecessary invasive fractional flow reserve.
C. It reduces the need for revascularization in patients after identifying physiologic stenosis by invasive coronary angiography (ICA) alone, by more accurately identifying if that stenosis is ischemic.
D. FFR measurement without need for adenosine and pressure wire
E. It reduces costs arising from inconclusive or inaccurate diagnostic tests
F. It avoids procedure costs for unnecessary ICAs (such as Angiography again).
G. It avoids staff and procedure costs for unnecessary interventions (such as angioplasty).
Computational Angiography Software
NiFFR
Non-Invasive Fractional Flow Reserved
MOBTAKERAN
SALAMAT
FAKHER
A: Analysis is done using standard X-ray angiography images with the need for three additional views and adenosine injection.
B: Like FFR, it allows accurate evaluation of stenotic lesions responsible for cardiac ischemia but reduces the need for invasive FFR.
C: It reduces the need for unnecessary revascularization by reliably identifying physiologically significant stenotic lesions (responsible for ischemic damage) as opposed to the lesions with less physiological significance.
D: It reduces the need for unnecessary revascularization by reliably identifying physiologically significant stenotic lesions (responsible for ischemic damage) as opposed to the lesions with less physiological significance.
E: It reduces the cost burden associated with inconclusive and inaccurate diagnostic studies.
F: It reduces the number of staff and procedure time, and also helps the physicians to avoid unnecessary procedures.
We will further expand on the meaning and significance of IMR and WSS measures.
The claimed benefits of NiFFR
NiFFR
Non-Invasive Fractional Flow Reserved
MOBTAKERAN
SALAMAT
FAKHER
Computation of NiFFR was performed online, using a computational simulation service. In the first step, two diagnostic angiographic projections, at least 25 apart, were selected.
The NiFFR: frame count analysis was performed separately on the two angiographic projections that were acquired during hyperemia.
Our company conducted a literature search on the diagnostic accuracy of NiFFR and the existing tests in the current treatment pathway for patients with coronary artery disease, against a reference standard of invasive FFR testing. the company presented diagnostic accuracy per-patient results for NiFFR compared with:
* Heart Flow FFR-CT
* Single-Photon Emission CT (SPECT)
* Stress Echocardiogram (ECHO)
* Magnetic Resonance Imaging (MRI)
Result Reserve
NiFFR
Non-Invasive Fractional Flow Reserved
MOBTAKERAN
SALAMAT
FAKHER
Pearson correlation was used to evaluate the correlation between
NiFFR and FFR. The NiFFR (correlation coefficient r=0.70, p<0.001) showed strong correlation with FFR for 245 patients (multi-center).